Several new publications by SweDeliver's junior researchers
SweDeliver's PhD students and postdocs continue to conduct studies of very high quality. In the autumn of 2021, Vicky Barmpatsalou, Staffan Berg, Vahid Forooqi Motlaq and Irès van der Zwaan have all presented interesting publications.
Vahid Forooqi Motlaq, PhD student in SweDeliver work package Parenteral Drug Delivery has published the article Investigation of the enhanced ability of bile salt surfactants to solubilize phospholipid bilayers and form mixed micelles in journal Soft Matter, issue 33, 2021.
In this study, Vahid Forooqi Motlaq et al. investigated the bile salt–phospholipid system NaDC–DMPC in physiological saline solution using a combination of the experimental techniques SLS, DLS, SAXS and cryo-TEM. In accordance, the team observed small ellipsoidal micelles that form spontaneously at high fractions of NaDC (XPL ≤ 0.5) and grow in size as the fraction of DMPC is increased.
Vicky Barmpatsalou, postdoc in SweDeliver work package Oral Drug Delivery has published the article Physiological properties, composition and structural profiling of porcine gastrointestinal mucus in journal European journal of pharmaceutics and biopharmaceutics, Vol. 169, 2021.
In this study, Vicky Barmpatsalou et al. used a larger animal species, the pig model, to characterize the mucus throughout the length of the gastrointestinal tract. This is the first report of the physiological properties (physical appearance, pH and water content), composition (protein, lipid and metabolite content) and structural profiling (rheology and gel network) of the porcine gastrointestinal mucus.
Staffan Berg, PhD student in SweDeliver work package Oral Drug Delivery has published the article In Vitro and In Vivo Evaluation of 3D Printed Capsules with Pressure Triggered Release Mechanism for Oral Peptide Delivery in journal Journal of Pharmaceutical Sciences, Vol. 110, 2021.
In this study, Staffan Berg et al. have evaluated a 3D printed capsule – designed to break from the physiological pressures in the antropyloric region – for its ability to deliver the synthetic octapeptide octreotide in beagle dogs when co-formulated with the permeation enhancer sodium caprate. The pressure sensitive capsules were compared to traditional enteric coated hard gelatin capsules and enteric coated tablets. Paracetamol, which is completely absorbed in dogs, was included in the formulations and used as an absorption marker to give information about the in vivo performance of the dosage forms.
Irès van der Zwaan, PhD student in SweDeliver work package Pulmonary Drug Delivery, has published the article Hyaluronic Acid Hydrogels for Controlled Pulmonary Drug Delivery – A Particle Engineering Approach in journal Pharmaceutics, issue 13, 2021.
In this study, Irès van der Zwaan et al. shows the feasibility of using spray drying to produce inhalation powders from hyaluronic acid hydrogels for possible controlled release pulmonary drug delivery. To this end, microparticles were prepared by spray drying from crosslinked as well as native HA. The obtained microparticles were subjected to extensive characterization, including chemical composition, particle morphology and size analysis, surface zeta potential, swelling, in vitro biodegradation and aerosolization performance.
Christel Bergström, Professor
Department of Pharmacy, Uppsala University
text: Magnus Alsne, photo: Mikael Wallerstedt, SweDeliver
Many new publications by SweDeliver's junior researchers
2022-06-21During the spring and early summer, Staffan Berg, Vahid Forooqi Motlaq, Ann-Sofie Persson, Maryam Tofiq and numerous other junior researchers at SweDeliver are publishing results that add valuable knowledge to the fields of drug delivery. ...
New Podcast: SweDeliver at the Speed Of Life
2022-06-20Meet Center directors Christel Bergström, SweDeliver, and Cecilia Persson, AM4Life, in a special edition of STUNS podcast Speed of life, discussing the possibilities and challenges that come with coordinating world leading research and competence cen...
Researcher profile: Anders Karlén coordinates the combat against the invisible enemy
2022-06-09“As long as disaster does not strike with full force, many prefer to look elsewhere,” says Anders Karlén, Professor of Computer-Aided Drug Design, who after coordinating the European flagship ENABLE now continues the fight against antibiotic-resistan...
New thesis with focus on microgels as tools for drug delivery
2022-05-24Tuesday 14 June Yassir Al-Tikriti, PhD student at SweDeliver and Uppsala University’s Department of Medicinal Chemistry, will present his thesis Microgels as drug delivery vehicles: Loading and release of amphiphilic drugs. ...
Innovation award to new molecules for drugs against covid-19
2022-05-24With the Attractive Innovation Project Award, the researchers behind CoLD Therapeutics are taking the next step in turning their newly developed substances into a pharmaceutical drug against covid-19. "Our project is attracting a lot of attention and...
The Faculty of Pharmacy congratulates its new doctors
2022-05-19In May, Uppsala University traditionally holds a Doctoral Degree Conferment Ceremony, a celebration for those who have received doctorates during the year. This year, the promotion takes place on both 18 and 25 May, since the January promotion had to...
The Faculty of Pharmacy ready for ULLA Summer School 22
2022-05-11In early July, Uppsala University’s Faculty of Pharmacy welcomes PhD students and researchers from all over Europe to the ULLA Summer School 22, a unique experience that will bring together the future leaders in international pharmacy. ...
Several new publications from SweDeliver's junior researchers
2022-04-21SweDeliver continues to conduct high quality research. In the spring of 2022, Vicky Barmpatsalou, Ilse Dubbelboer, Agnes Rodler and Yassir Al-Tikriti are publishing articles that add important knowledge to the field of parenteral and oral drug delive...
ENABLE-2 takes the lead in the pursuit of new antibiotics
2022-03-21The Swedish Research Council's investment in ENABLE-2 has, with support from Vinnova, launched with four projects that are considered very promising in the pursuit for new antibiotics. In the first round of admissions, two projects from Uppsala Unive...
Insects in the Fyris river carried 33 different pharmaceutical substances
2022-03-18In a study of insects in the Fyris river, researchers identified traces of 33 different pharmaceutical substances. "In combination, these substances can give unexpected and amplified effects that, when they reach further up the food chain, might also...
New substances to provide better diagnosis and treatment of prostate cancer
2022-03-03Researchers at Uppsala University have developed two new substances that show positive results for early detection of metastases in prostate cancer. "If only one of our two leads is successful, we hope to be able to help all men suffering from prosta...
PhD Student competition: Present your research in three minutes
2022-03-02All PhDs students at the Faculty of Pharmacy and Uppsala University are invited to participate in the qualifying round for a competition where you present your research in a maximum of three minutes. The competition is organised by the Coimbra intern...
Faculty of Pharmacy welcomes 200 PhD students to ULLA 22
2022-02-10July 2–9, the Faculty of Pharmacy will be at the center of European pharmaceutical research when Uppsala University hosts the ULLA Summer School. "I am sure that we will all experience a unique summer school that adds important values to both tra...
New results on stabilising the boundary between collapsed and swollen phases in microgels
2022-02-01In a new article published in Gels, Yassir Al-Tikriti, PhD student at SweDeliver and the Department of Medicinal Chemistry, presents results supporting the hypothesis that the boundary between collapsed and swollen phases in the same microgel is stab...
ENABLE-2 ready to lead continued development of new antibiotics
2021-12-21ENABLE, the EU initiative for antibiotic development led by Uppsala University, will continue its work in ENABLE-2 with financial support from the Swedish Research Council. "An independent committee have chosen between many interesting project propos...
Experts in pharmaceuticals are positive about future virus control
2021-12-20“There is much to suggest that in the near future we can fight infectious viruses much faster than today”, says Anders Hallberg, medicinal chemist at Uppsala University and member of the Royal Swedish Academy of Science and its expert group, who in a...
Several new publications by SweDeliver's junior researchers
2021-12-13SweDeliver's PhD students and postdocs continue to conduct studies of very high quality. In the autumn of 2021, Vicky Barmpatsalou, Staffan Berg, Vahid Forooqi Motlaq and Irès van der Zwaan have all presented interesting publications. ...
Present your research at SciFest 2022 – Registration open now
2021-11-01The Uppsala science festival SciFest returns to Fyrishov. 10–12 March 2022, researchers from Uppsala University and thousands of curious schoolchildren and adults will meet for a variety of activities, shows and lectures. As a researcher at the Facul...
SEK 25 million to ENABLE-2 and continued development of new antibiotics
2021-10-06ENABLE, the EU initiative for antibiotic development led by Uppsala University, has received SEK 25 million from the Swedish Research Council to start up ENABLE-2. "We are already accepting project proposals and hope that this investment will inspire...
MSI Lab Per Andrén joins SciLifeLab Spatial Omics
2021-09-16With the launch of national resource Spatial Omics, SciLifeLab consolidates Sweden's advanced position in one of the hottest fields of science. "This gives us the capacity to extract even more detailed knowledge from cell and tissue analyses," states...
Webinar about your possibilities at Testa Center
2021-09-14Testa Center provides Uppsala University’s researchers access to state-of-the-art equipment for drug and bioprocess development. At the webinar "Academic research in the Testa Center – A testing bed for upscaling your biological innovations", you w...
Andrea Benediktsdottir is awarded the Iris Scholarship for aspiring women
2021-08-13Andrea Benediktsdottir, PhD student at the Department of Medicinal Chemistry, is awarded the Iris Scholarship for aspiring women in Sweden. With the scholarship, Andrea Benediktsdottir will participate in an interdisciplinary course focusing on antib...
SciLifeLab – A national research infrastructure in Uppsala
2021-06-18SciLifeLab is a national research infrastructure in life sciences with Uppsala University as one of four host universities. Today, SciLifeLab conducts operations at most major Swedish universities. ...
New research to improve use of amphiphilic drug molecules
2021-05-19By exploring the aggregation properties of different amphiphilic molecules in microgels, Yassir Al-Tikriti, PhD student at the Department of Medicinal Chemistry, aims to provide tools and knowledge of importance for future cancer therapies and antide...
New seminar series puts focus on Swedish drug development
2021-04-19This spring semester, SweDeliver and NextBioForm invite to online lunch seminars. Welcome to experience frontline research with a focus on industrial challenges in drug delivery and the development of biologically based drugs. ...
Olof Eriksson receives SEK 1,3 million for PET project
2021-04-19Olof Eriksson, researcher in translational imaging, is awarded a Project Grant of SEK 1,303,000 from Diabetes Wellness Sweden for his project GPR44 as a PET marker for measuring beta cell mass in human. ...
New biomarkers can lead to breakthrough in diabetes research
2021-04-19With the discovery of two new biomarkers, Olof Eriksson, researcher in translational imaging, may lead the way to the scientific breakthrough that will enable curative drugs and personalised treatments for diabetes. ...
Apply for funding for postdoc exchange between the Faculty of Pharmacy and SLU
2021-04-19Funding is now available for two postdoc exchanges, one hosted by the Faculty of Pharmacy or Fauculty of Medicine at Uppsala University, and one by a department at the SLU Faculty of Veterinary Medicine and Animal Science ...
Here you can read more research news at the Department of Medicinal Chemistry