In chemical biology, synthetic organic chemistry allows us to access a range of tools for exploring research questions within a biological framework. In particular, we are interested in synthesising and evaluating small molecule probes to investigate their biological targets in both humans and bacteria. Ultimately, we aim to develop novel, selective antibiotics that will allow us to eradicate pathogenic bacteria whilst minimising collateral damage against our commensal microbes.
Areas of interest:
- Elucidating the biological targets of bacterially produced small molecules
- Molecular mechanisms of colonization resistance
- Electrophilic natural products
- Expanding the bioorthogonal chemistry toolkit
- New modalities in antibiotic drug design
This work is supported by the Uppsala Antibiotic Centre (https://www.uac.uu.se).