ERC Grant for research on new method to diagnose and treat inflammatory bowel disease
Just a minute… Alexandra Teleki, researcher in drug development, who receives 2 million euros from the European Research Council to develop a new method to diagnose and treat inflammatory bowel disease in children.
How will you use the ERC Consolidator Grant?
“The field of chronic inflammatory bowel diseases faces many major challenges. We need to increase our knowledge about what causes them; we also need effective tools for diagnosis and treatment. Historically, they have mainly occurred in Europe and North America, but are now spreading in recently industrialized countries, for example in Asia. Every fourth patient develops the disease already as a child, but the methods available to healthcare entail significant risks for a young body. We want to change that.”
How will you proceed?
“Today in children, an endoscopic examination with sampling of biopsies under anesthesia is required to identify where in the gastrointestinal tract the inflammation is located and how active it is. Thereafter, healthcare can adapt the treatment to reduce the inflammation. We want to enable a transition to magnetic resonance imaging, which is performed without either physical intervention or ionizing radiation. We will do this with a nanoparticle that localises the inflammation and determines its activity. With nanoparticles, we will also transport drugs and release the right dose locally in the gastrointestinal tract. The particle itself is administered orally and is biocompatible and non-toxic, which facilitates treatment at home.”
What will make your work successful?
“The particle we use is simple to produce and flexible in size and composition. Our biggest challenge will be to identify biomarkers that indicate inflammatory bowel disease and that the particle can bind to in the gastrointestinal tract, but even here it looks very promising. We recently published a study in which we mapped preclinical biomarkers that meet our needs. We have also gathered a very competent project group with leading environments at Uppsala University's faculties of pharmacy and medicine, SciLifeLab, Uppsala University Children's Hospital and the University of Florida. Overall, it makes me confident that we will succeed.”
What significance can your work have in healthcare?
“As a child, developing inflammatory bowel disease is a demanding and traumatic experience in many ways. We want to simplify the diagnosis and treatment they have to undergo, and naturally hope that our results can also be transferred to adult patients. Our ambition is that the technology can also be applied to diagnose colon cancer - for which inflammatory bowel disease is an important indicator, and has therefore initiated collaboration with cancer researchers at Umeå University.”
- The Project MAGNETO: Nanoengineered magnetoresponsive diagnosis and personalized treatment of pediatric inflammatory bowel disease will last 2021–2025
- The work is funded by the European Research Council with a EUR 2 million ERC Consolidator Grant.
- The work will be led by Alexandra Teleki, the Faculty of Pharmacy, SciLifeLab and Uppsala University.
- The project group includes
- Christel Bergström and Per Artursson, Faculty of Pharmacy, Uppsala University
- Mia Phillipson, Faculty of Medicine, Uppsala University
- Niklas Nyström and Mattias Paulsson, Gastroenterology clinic, Uppsala University Children's Hospital
- Carlos Rinaldi, Department of Chemical Engineering, University of Florida
- Proteomics-Informed Identification of Luminal Targets For In Situ Diagnosis of Inflammatory Bowel Disease
- Hermetically Coated Superparamagnetic Fe2O3 Particles with SiO2 Nanofilms
- Current research in Drug development
- Lab Teleki
Alexandra Teleki, Assistant Professor
Department of Pharmacy
text: Magnus Alsne, photo: Teleki Lab
Master thesis at Testa Center opened international doors
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New technology paves the way for vaccination against cancer
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Anne-Lie Svensson receives Distinguished Teaching Award
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They receive the Pharmaceutical Student Union's pedagogical awards
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SweDeliver welcomes Janssen Pharmaceutica (BE) as new partner
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Make your lectures interactive with Mentimeter
Uppsala University now offers all employees a site license for Mentimeter: the web application that provides the opportunity to include interactive elements in your presentations and lectures.
Webinar 14 June: Digitalization, medicine and pharmacy
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Webinar 16 September: Swedish pharmaceutical research and the way forward
On Thursday 16 September, the Swedish Pharmaceutical Society and IF's foundation for pharmaceutical research invite you to a webinar with future explorations and retrospective aspects on how Sweden will regain its leading position in the world of pharmaceuticals.
Webinar 27 April • Testa Center for Academia
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New test environment shows unknown sides of zebrafish
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Apply for funding for postdoc exchange between the Faculty of Pharmacy and SLU
Funding is now available for two postdoc exchanges, one hosted by the Faculty of Pharmacy or Fauculty of Medicine at Uppsala University, and one by a department at the SLU Faculty of Veterinary Medicine and Animal Science.
New study: One in ten with COVID-19 experiences long-term effects
The ongoing COMMUNITY study at Danderyd University Hospital shows that every tenth employee who has had COVID-19 still experience problems that affect their quality of life negatively after eight months.
Webinar: Fighting the covid pandemic using pharmacometrics
Can BCG vaccine protect us against covid-19? On Thursday 22 April, Ulrika Simonsson, Professor of Pharmacokinetics, will present her work in the international research consortium currently exploring a vaccine to fight the ongoing pandemic. Welcome to join online!
Gambling strategies can be linked to the brain's reward system
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Pharmacy honorary doctor Mary Jeanne Kreek in memoriam
Mary Jeanne Kreek, world-renowned researcher, clinically active professor in the field of addiction at Rockefeller University, NY, and honorary doctor at Uppsala University's Faculty of Pharmacy passed away on the night of Sunday 28 March 2021.
Now comes the tools with the potential to revolutionise cancer research
With the upcoming launches of his award winning method to analyse protein activity in cells and a new artificial enzyme, Ola Söderberg, Professor of Pharmaceutical cell biology, aims to provide game changing tools to the fields of cancer research and cell biology.
New online course: Advanced cancer biology
Welcome to join the new course Advanced cancer biology, 7–11 June, covering important topics in the field of tumor biology. The course is primarily aimed at PhD students, postdocs and researchers. Apply no later than 14 April 2021.
Make your nomination for Alumnus of the Year 2021
Who among the Faculty of Pharmacy's many alumni do you think best deserves the Alumnus of the Year 2021 award at Uppsala University? You are welcome to nominate your candidate no later than 2 May.
Alumnus in focus: Erik Fredholm, vaccine coordinator in Region Örebro
Erik Fredholm, pharmacist in Region Örebro, has seen his working days change along the spread of the coronavirus. Three months have passed since he last took a break. At the moment he estimates that it will take another three months before his next visit to the coffee room.
The Faculty of Pharmacy top-ranked for higher education
In the QS World University Rankings, Uppsala University is ranked no. 37 in the world for studies in Pharmacy & Pharmacology. "This proves that our work at Uppsala University gives results, and also gives us important inspiration for the future," says Mathias Hallberg, Dean of the Faculty of Pharmacy.
New courses in drug development meet industrial needs
As academic hub in the competence center SweDeliver, the Faculty of Pharmacy is consolidating its already advanced position in drug delivery. In the autumn of 2021, a new step is taken with a series of four courses that respond to the field's extensive need for future competence.
The Faculty of Pharmacy puts focus on Drugs in the environment
In September 2021, Uppsala University will launch the new course Drugs in the Environment, developed in collaboration with the Swedish MPA's Knowledge Center for Drugs in the Environment. The initiative unites a number of leading organisations in order to provide Sweden with long-term tools to meet a rapidly escalating challenge.
The doctoral student council is looking for new board members
The Pharmaceutical Doctoral Student Council (FDR) is the Pharmaceutical Student Union's PhD student council, representing the PhD students at the Faculty of Pharmacy in committees and boards. Our focus is to ensure that all PhD students can complete their studies in a good working environment and under good employment conditions. Now FDR is looking for new board members 2021/22.
Nominate your candidate for the 2021 Oscar Prize
The Oscar Prize, one of Uppsala University's most prestigious awards, is given to a young researcher "whose scientific writing is the most deserving and offers the greatest promise of continued academic writings at the University ". Welcome with your nomination no later than March 25.
Faculty of Pharmacy at SciFest 2021
4-10 March 2021 the SciFest science festival welcomes pupils and adults from all over Sweden to take part in lectures, shows and hands on activities. Of course, the Faculty of Pharmacy's researchers will be online to provide insights into how a drug is developed and utilised.
Olof Eriksson receives SEK 1,3 million for PET project
Olof Eriksson, researcher in translational imaging, is awarded a Project Grant of SEK 1,303,000 from Diabetes Wellness Sweden for his project GPR44 as a PET marker for measuring beta cell mass in human.
Apply for grants for Educational Renewal and Pedagogical Development
Teachers and teaching teams at the Faculty of Pharmacy can now apply for project funding for renewal of education and pedagogical development. The call is for the financial year 2022, but grants may be used from autumn 2021.
New results show broad immunity against covid-19 after nine months
96 percent of those who develop antibodies to SARS-CoV-2 still carry them after nine months shows research at Danderyd University Hospital, Uppsala University and KI. The results are based on the third phase of the COMMUNITY study, examining long-term immunity after covid-19.
Björn Wettermark creates tools for optimised drug utilisation
The path of the drug from laboratory to patient is long and every year non-optimised medication use costs both human lives and astronomical amounts. Now, Björn Wettermark, Professor of Pharmacoepidemiology, is forming the multidisciplinary clusters than can help turn the tide.
Faculty of Pharmacy is ready for ULLA Summer School 2021
July 6-8, the Faculty of Pharmacy will be at the center of European pharmaceutical research when Uppsala University hosts the ULLA Summer School, a meeting place that brings together the future leaders in international pharmacy. "I am convinced that we will create a unique experience," says Andrea Benediktsdottir of the organising committee.
New biomarkers can lead to breakthrough in diabetes research
With the discovery of two new biomarkers, Olof Eriksson, researcher in translational imaging, may lead the way to the scientific breakthrough that will enable curative drugs and personalised treatments for diabetes.
Drugs in the Environment one of many new freestanding courses at the Faculty of Pharmacy
In 2021, the Faculty of Pharmacy is expanding its already wide range of freestanding courses. This year’s news includes Drugs in the Environment, Biologicals and Introduction to Nanomedicine - themes that respond well to society's challenges.
New seminar series puts focus on Swedish drug development
This spring semester, SweDeliver and NextBioForm invite to online lunch seminars. Welcome to experience frontline research with a focus on industrial challenges in drug delivery and the development of biologically based drugs.
Apply for the best summer job of 2021 at SweDeliver
In the summer of 2021, SweDeliver will give five students the opportunity to conduct research on site at one of our industrial partners. Each project will extend over six weeks and constitute a platform for future recruitment of advanced students and PhD students to our competence center.
New research to enable increased drug doses to the lung
By exploring the physical stability of particles during pulmonary drug delivery, Sohan Sarangi, PhD student at SweDeliver and the Faculty of Pharmacy, is providing important knowledge about optimising the amount of drug delivered to the lungs.
Apply now and become the faculty's 8th Distinguished University Teacher
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Uppsala's MSI environment continues to expand
Just a minute… Per Andrén, Professor of Mass Spectrometry Imaging, that with the installation of a new FTICR instrument heads of one of the world's leading facilities for Mass Spectrometry Imaging.
New route for foreign pharmacists to Swedish labor market a success
In 2017, Uppsala University launched a Complementary Programme and a Proficiency test for newly arrived pharmacists. Today, the participants account for one in four applications for Swedish pharmacist licenses. "Everyone is extremely motivated," says Shima Momeni, coordinator at the Faculty of Pharmacy.
Testa Center and the Faculty of Pharmacy take bioscience to the next level
At Testa Center, researchers and teachers at the Faculty of Pharmacy have access high-quality laboratory environments. Here they meet the infrastructure and expertise required to take their innovations and students to new heights.
Nominate your candidate for The Distinguished Teaching Awards
Which teacher at the Faculty of Pharmacy has made the most outstanding contributions in undergraduate education? Nominate your candidate for the Uppsala University Distinguished Teaching Awards 2021 no later than 18 March.
New findings on adverse effects of L-Dopa therapy of Parkinson's disease
To treat Parkinson's disease with L-Dopa will gradually deteriorate in effect and cause involuntary movements. In a new study, researchers at Uppsala University link this to a dysregulation of L-Dopa metabolism throughout the brain.
Interdisciplinary collaboration provides new answers about immunity after Covid-19
Only weeks after the coronavirus reached Sweden, blood samples were taken from more than 2,000 employees at Danderyd Hospital. Today, a selection of the country's leading researchers collaborate with this unique material within the COMMUNITY study to extract new knowledge needed to fight covid-19.
New methods to predict release and absorption of orally administered drugs
Friday 15 January at 09.15 Caroline Alvebratt, PhD student at the Department of Pharmacy, will defend her dissertation with focus on new methods to predict the release and absorption of orally administered drugs. Welcome to participate online via Zoom.
Sooraj Bajinath wins Bioanalysis Rising Star Award 2020
Sooraj Baijnath, researcher of Medical Mass Spectrometry Imaging, is the winner of the Bioanalysis Rising Star Award 2020. “It has been overwhelming to see the amount of support I have received globally,” says Sooraj Baijnath.
They won the Faculty's X-mas gift competition 2020
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New thesis explores the evolution of sponge species in Antarctica and the deep sea
Thursday 17 December at 1 PM, Vasiliki Koutsouveli, PhD student at the Department of Pharmaceutical Biosciences, will defend her thesis focusing on the ecophysiological and evolutionary aspects of sponge species from Antarctica and the deep sea. Welcome to participate online via Zoom.
New analysis method for predicting the risks and effects of immunotherapy
In a new study, researchers at Uppsala University have been able to show differences in how Rituximab, a monoclonal antibody drug, interacts with the blood of healthy individuals compared to patients with chronic lymphatic leukaemia. This has awakened hopes that this analysis method could pave the way for important breakthroughs in immunotherapy research and treatment.
ERC Grant for research on new method to diagnose and treat inflammatory bowel disease
Just a minute… Alexandra Teleki, researcher in drug development, who receives 2 million euros from the European Research Council to develop a new method to diagnose and treat inflammatory bowel disease in children.
Apply now for the Swedish Pharmaceutical Society scholarships
Post docs, PhD:s & Students in the field of pharmacy can now apply for scholarships for, among other things, research courses and congresses. Apply no later than 31 January 2021.
Be a winner in this year's X-mas gift competition
With glühwein and a well deserved vacation just weeks away, the Faculty of Pharmacy strikes with the hottest event of the year: The X-mas gift competition 2020. Three lucky winners will receive an extra present in their stockings that will make them the department's most admired employees the entire 2021.
Ebba Bergman and Phil Harrison win the Adipocyte Cell Imaging Challenge
Ebba Bergman and Phil Harrison, PhD students at the Department of Pharmaceutical Biosciences, are winners of the Adipocyte Cell Imaging Challenge – AI Sweden and AstraZeneca's challenge to create a solution to avoid using staining when testing new drugs on cell cultures.
New research raises hope of curing Alzheimer's disease
"Our ambition is to apply the method to humans in the foreseeable future," says Greta Hultqvist, researcher at Uppsala University, who with a new protein transporter has succeeded in stopping and reversing the development of Alzheimer's disease in mice.
Here, pharmaceutical experts are educated to make Swedish healthcare even more efficient
With the task to optimise each patient's drug situation, the clinical pharmacists have in a short time become a welcome reinforcement in the Regions' care teams. At Uppsala University, Sweden's only Master's Programme in Clinical Pharmacy is offered, and the demand for the students' competence is high.
See webinar on the opportunities offered at Testa Center
At Testa Center, researchers and students at Uppsala University have access to modern equipment for drug and bioprocess development. In this webinar, recorded during Innovation Week 2020, experiences and examples of the work performed are presented. (webinar in Swedish)
SSF illustrates Erik Jansson's research in new film
Erik Jansson, researcher at the Department of Pharmaceutical Biosciences, explains in a new film from the Swedish Foundation for Strategic Research his work of increasing our knowledge of the body's signaling system between brain and cells.
Sara Mangsbo receives SITC Team Science Award
Sara Mangsbo, researcher at the Faculty of Pharmacy, receives the 2020 SITC Team Science Award for her work contributing to new cancer treatments.
The SweDeliver Scientific Advisory Board identifies great potential
“Our Scientific Advisory Board expressed that SweDeliver is moving in the right trajectory, providing a unique ecosystem with great potential to exceed the needs of all stakeholders,” states Christel Bergström, Center director at Sweden's new competence center for Drug delivery.
Swedish Research Council grants SEK 6.6 million to Daniel Globisch and Ola Spjuth
Daniel Globisch and Ola Spjuth, researchers at Uppsala University's Faculty of Pharmacy, are granted a total of SEK 6.6 million in the Swedish Research Council's call Natural and engineering sciences. The grants are to be received during 2020–2024.
Elin Svedin is new chairwoman of the Alumni Association Farmis
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Eight months of distance learning: "We are approaching a critical point"
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Sara Mangsbo: Prize-winning innovator focused on immunotherapy
Over the past decade, more and more biopharmaceuticals have been developed for anti-cancer immunotherapy. Sara Mangsbo is actively contributing to their development with her research group, and has also started three companies. She was recently awarded the Uppsala University Innovation Prize, Hjärnäpplet, for her ability to combine research and entrepreneurship.
Two new awards to researchers at the Faculty of Pharmacy
Maria Karlgren and Christine Wegler, researchers at the Faculty of Pharmacy, receive awards for their work contributing to reduce the number of animal studies and increased knowledge about drug disposition in the liver and small intestine.
Swedish Research Council grants millions to research at the Faculty of Pharmacy
Per Artursson, Olof Eriksson, Hans Lennernäs and Ola Spjuth, researchers at Uppsala University's Faculty of Pharmacy, have been granted a total of SEK 16.68 million in the Swedish Research Council's call Medicine and Health. The grants will be received during 2020–2024.
Uppsala researcher in EU-initiative for better medication adherence
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SweDeliver's junior researchers prepare their next career step
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The Diversity report: Varying images that require further analysis
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New model to provide more accurate predictions in drug treatment
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New study aim to provide safer oral administration of macromolecular drugs
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Present your research at SciFest 2021
The Uppsala science festival SciFest goes digital. March 1–6, 2021, researchers from Uppsala University and curious schoolchildren and adults from all over Sweden will meet for a variety of lectures, shows and activities. As a researcher at the Faculty of Pharmacy, you can now register your participation.
New facility takes up the chase for doped athletes and future drugs
Using a home-grown filamentous fungus, Mikael Hedeland, professor of analytical pharmaceutical chemistry, managed to expose four medalists guilty of doping at the Olympic Games in Athens. Now he is refining his methods further, opening a facility for mass spectrometry at the Uppsala Biomedical Center.
Self-learning machines take the step into drug discovery
In the winter of 2020, a novel robotised laboratory for cell profiling will open at Uppsala's Biomedical Centre – a high-tech facility ready to deliver as the Knut and Alice Wallenberg Foundation now invests SEK 3.1 billion in making Sweden a world leader in computer-driven life sciences.
Se onlineseminarium om problemspelande i en föränderlig omvärld
I oktober inbjöd Uppsala universitets Forum för forskning om läkemedels- och drogberoende (U-FOLD) och Svenska Spels oberoende Forskningsråd till Öppen Forskningsdag i syfte att belysa det senaste inom forskningsområdet kring hasardspel. Experter vid flera universitet och högskolor deltar i mötet som du nu kan se online.
SEK 9 million to research on personalized drugs for children suffering from severe diseases
Christel Bergström, Professor of Molecular Pharmaceutics, receives SEK 9 million from the Erling-Persson Family Foundation in continued support of the project Personalized medications for children suffering from severe diseases.
New method enables earlier answers during drug development
With the Nobel Prize-winning technology CRISPR-Cas9, researchers at Uppsala University are creating new components for more efficient drug development with fewer animal experiments.
Researchers at the Faculty of Pharmacy praise this year's selection of Nobel Laureates
To contribute to better treatment and reducing the spread of the viral disease hepatitis C is prioritized work at Uppsala University's Faculty of Pharmacy, where researchers praise the 2020 selection of Nobel laureates in physiology or medicine.
The SweDeliver Pulmonary Drug Delivery Work Package – An ecosystem for research and competence development
“The national competence center SweDeliver has already extended the visibility and appeal of the Faculty of Pharmacy far beyond Sweden's borders. This enhances our ability to recruit top-of-the-line PhD students and postdocs.”, states Göran Frenning, Professor of Pharmaceutical Physics and leader of the Pulmonary Drug Delivery Work Package.
Former Vice-rector Stellan Sandler is awarded the Gustaf Adolf Medal
Stellan Sandler, professor of medical cell biology and former Vice-rector at the Disciplinary Domain of Medicine and Pharmacy, is awarded the older Gustaf Adolf Medal in gold for his significant contributions to Uppsala University.
What’s on at the Faculty? – 13 October 2020
Welcome to What’s on at the Faculty of Pharmacy? We will meet online via Zoom. The program contains current issues, our faculty’s diversity report and popular science presentations. We will end with coffee&quiz at BMC.
The Faculty of Pharmacy congratulates its newly graduated pharmaceutical experts
A new generation of pharmaceutical experts has received their diplomas and is entering their professional life. Saturday 26 September, the Faculty of Pharmacy held the 2020 graduation ceremony - which this year was four.
Webinar 6 October: Testa Center and Uppsala University developing for required cutting-edge competence
At Testa Center, students at Uppsala University receive training in bioprocess- and drug development, while researchers get access to modern equipment in the biotechnological process industry. In this webinar at Innovation Week 2020, students and researchers talk about their experiences at the Testa Center.
Apply for travel grant for travels April–September 2021
Apply no later than 15 October for the Vice-Chancellor’s travel grant for travels April–September 2021. Grants are awarded for travels that most benefit a personal scholarly exchange and is of use to Swedish research.
Sofia Kälvemark Sporrong: Sweden needs more pharmacy rebels
Eleven years after the deregulation of the pharmacy market, Sweden is facing another comprehensive reform. Now with healthcare in focus. And once again, a distinct pharmaceutical voice is missing in the debate. "It is time for the profession to make themselves heard," says Sofia Kälvemark Sporrong, Professor of Social pharmacy, returning to Sweden and Uppsala University.
Researcher profile: Sara Mangsbo explores new ways to fight cancer
At the forefront of one of science's most successful fields. Entrepreneur of the year and ready to give another company a flying start. Sara Mangsbo, researcher in immune-oncology at Uppsala University, follows her own advice and looks far beyond the comfort zone.
The SweDeliver Oral Drug Delivery work package – A gold mine for junior researchers
“Here, PhD Students and postdocs interact with leading research groups, aspiring start-ups and established companies. It is a dynamic environment that will ensure continued growth in the already dynamic Swedish life science sector.”
Vice-rector Mats Larhed: What we do now will shape our disciplinary domain for many years to come
After nine years as deputy Vice-rector, Mats Larhed takes the next step. The To-do list is extensive and 5-6 October, he will gather the disciplinary domain staff and students for Vision: Medfarm. An initiative that will point out a mutual direction forward.
SweDeliver Parenteral drug delivery – Home to a diversity of high-quality research
At SweDeliver's research environment for parenteral drug delivery, industry and Uppsala University's Faculty of Pharmacy meet to develop new systems for injected drug administration. It is an arena characterized by commitment, trust and a mutual movement forward.
Watch U-FOLD seminar on gambling addiction during the Corona crisis
Wednesday 16 September, U-FOLD focused on gambling problems and addiction in relation to aggressive advertising, mental illness and Covid-19. The webseminar was attended by, among others, Minister for Social Security Ardalan Shekarabi (S).
Digital (bad)habits present new challenges to addiction researchers
Hundreds of thousands of Swedes caught in the web of online casinos. Children who sit glued to screens, risking their future physical and mental health. New technologies have made the path to addiction more of a maze than ever before.
New knowledge about NAT2–enzyme can help improve drug dosages
Researchers at Uppsala University have identified previously unknown activity in the enzyme NAT2 affecting the body's metabolism and clearance of drugs. The study, expected to contribute to tailor-made drug treatments, is published in Angewandte Chemie International Edition.
Continued increase in applicants for the Master of Science Programme in Pharmacy
In the second selection for admissions to the autumn term, 115 students were admitted to the Faculty of Pharmacy's Master of Science Programme in Pharmacy. 90 students were admitted to the Bachelor of Science Programme in Pharmacy.
Here we present more news from the Faculty of Pharmacy at Uppsala University: